3D Fantasy Zone: Opa-Opa Bros. is an enhanced port of the Sega System 16 version of Fantasy Zone for the Nintendo 3DS released as part of the 3D Classics range.

3D Fantasy Zone: Opa-Opa Bros. enhances the game in various ways. Locating enemy bases has been made easier as a map is displayed on the touch screen to pinpoint their locations, along with optional markers displayed on-screen to direct the player. Coins collected in gameplay are saved to a "Coin Stock", allowing the player to withdraw some money when starting a new game.

Other new features include saving replays, savestates, and a stage select.