AMF Xtreme Bowling 2006 is a bowling simulation game. It has nine environments, all in regular or "xtreme" versions, colorful customizable characters whose stats increase as you play, customizable oil dispersion on the lane and six modes.

The modes available are practice, single player, which are self-explanatory, tournament and league, which support up to 8 alternating players and match challenge where you must attempt to get strikes with various pin arrangements of increasing difficulty.