In Android Assault an alien species called the Xias have targeted human beings for extermination. They have assembled a massive fleet that has crushed any opposing ship that has been sent their way and has started to attacking colonies stationed on nearby planets with a collision course to Earth and it is up to the player to stop them.

The gameplay is a side-scrolling shooter, similar to R-Type, where the player takes control of a space fighter that can morph into a cyborg called Bari-Arm and has an arsenal of weaponry to take down enemy ships including the Thundercracker, Burning Wave and the Chase Cannon along with picking up health and power-ups left behind by destroyed enemies.