Atelier Iris: Eternal Mana is a Turn-Based RPG and with alchemy gameplay and story components. It is the 6th core Atelier game and the first game in the Iris series, being the first Ateleir game to be released internationally.

The game follows the young alchemist Klein Kiesling, who is travelling to learn more about alchemy together with his friend, the Wood Mana, Popo. One day, he is saved from a monster by Lita Blanchimont, a young Galgazit, monster hunter. Lita eventually recruits him to become an Galgazit as well, and they start working together in the town of Kavoc. However, Klein is soon caught in many troubles, and eventually becomes involved in a quest of saving both the world and Lita.