In the year 2001, a virus has killed 99.99% of the females on Earth. Various countries fight over each other's quarantine zones, and end up engaging in nuclear war, destroying much of civilization. The few remaining females are held by gangs who have taken over small pieces of the world. The main character, Griffin Spade, had his fiancee Madison taken away from Queens, New York by the U.S. Government. Griffin ends up separated from his fiancee, and New York City is destroyed. He claims a tank for his own and sets out to cross America and find her, battling gangs as he reaches his goal. After surviving the ruins of New York City, Griffin heads westward gaining recruits in the countryside, Chicago, Las Vegas, and San Francisco.