Centipede: Infestation is a video game developed by WayForward Technologies and published by Atari, SA for the Nintendo Wii and the Nintendo 3DS. It is a re-imagining of the Centipede video game franchise.

Centipede: Infestation is set in a post-apocalyptic world, and features a "run 'n' gun" shooting style gameplay with a mix of tower-defense style objects. The player's goal is to fight off giant bugs while seeking to use special seeds to bring plant life back to the world. Players control a character named Max as well as secondary character named Maisy who possesses a collection of special needs. She is often in need of rescue. The game has co-op gameplay,and a wide variety of weapons and stages. The co-op part of the game features a selection of characters to choose from and it is much easier to get through the game with a friend.