Take the role of private detective John McAffrey and step into a world of trouble in Cold Zero. A deal-gone-wrong has the hero indebted to the mob. He is asked to put his skills of stealth and tactics to use for his underworld overseers. His first mission has him sneaking inside a bioresearch facility and stealing a virus known as "Cold Zero." But what exactly is this virus? Is delivering it to the mob the smart thing to do? Players must find out for themselves as they play through this dark adventure.

The missions can be completed using stealth or full out combat. There are 100's of different weapons including melee weapons. You can also pick up objects from dead bodies which you can pawn for cash.