Ever since she could remember, Akitsu Shino has had the ability to see what others could not: spirits, apparitions, and indescribable creatures. As an adult, this talent leads her to join a secret government agency: The Occult Action Department. Her assignment is with the Sixth Special Preventions Office, and her job is to monitor the powerful beings who travel between her world and the worlds beyond.

From her office in Sakuratani, a town in a different dimension, Agent Shino meets several otherworldly individuals with vastly different personalities and abilities: a nine-tailed fox spirit, a mischievous oni, and more. Part gatekeeper, part travel guide, she does her best to get to know these entities and keep them from getting into inter-dimensional trouble.