Duke Nukem 3D for the Tiger Game.com is a handheld first-person shooter inspired by the PC version, though it is profoundly different from the original.

It plays more like a dungeon crawler rather than an FPS due to Game.Com's hardware limitations. The player can only move Duke forward, backwards, strafe left or right, one screen at a time. By pressing B or C the player can turn Duke to shoot left or right, but can't turn him to face that direction and move.