Puyo Puyo! 15th Anniversary was created by Sonic Team to commemorate the 15th anniversary of Puyo Puyo. As such, it revives both the gameplay rules of the arcade Puyo Puyo and Puyo Puyo Tsu, as well as six characters from the Madou Monogatari era of the series.

It was released for Nintendo DS in 2006, and in 2007 for PlayStation 2, PlayStation Portable, and Wii

This game was followed by Puyo Puyo 7.