Shin Megami Tensei II is a port of the PlayStation remake of Shin Megami Tensei II with new content exclusive to Game Boy Advance version. However, this port also has washed out colors and lower quality music than its PlayStation counterpart, due to hardware capabilities of Game Boy Advance.

The gameplay uses first-person navigation of dungeons and turn-based battles against demons. The player can recruit demons as allies by talking to them rather than fighting them, and two to three demons can be fused to create new demons.