The PlayStation 2 and Wii version of Spider-Man 3, a videogame based on the 2007 movie of the same name.

The gameplay in this version closely resembles that of its next-generation counterpart, with the main difference being that the combat system primarily takes place on the ground.

The primary features of the Wii version are motion controls. By flicking the Wii Remote & Nunchuck, the player can perform various actions such as combat, and one of Spider-Man's trademark abilities, web swinging. There are also certain mini-games tailored to the motion controls.