In The Caligula Effect 2 a virtuadoll named Regret has created the world of Redo in order to save people from their past regrets by unknowingly imprisoning them in a simulation. However, this "paradise" is shaken to the core when a virtual idol named X breaks into Regret's virtual reality and restores a high school student's memories of the real world. In order to escape Redo, they re-establish the Go-Home Club, a resistance group that seeks to fight against Regret and her enforcers, the Obbligato Musicians.

The First Press Limited Edition contains:
- Game: The Caligula Effect 2
- Special album CD Side
- Special art book (100 page)
- Oguchi-illustrated image reproduction
- The Caligula Effect 2 documentary movie DVD
- Additional music DLC
- In-game item DLC
- Special illustrated box