Toxic Crusaders is a 2D platform game, based on the TV show Toxic Crusader and Toxic Avenger character.

Between each level, the player can select the Crusader they want to play as: Toxie, No-Zone, Major Disaster, Headbanger and Junkyard.

The gameplay is standard for side-scrolling platform games: the player goes to the right, shoots enemies, jumps on hills and avoid obstacles. All characters have unlimited ammo.