Released in Japan in 1997, Vampire Savior 2 was released along side Vampire Hunter 2 and uses the same gameplay mechanics as Vampire Savior. The game adds Night Warriors: Darkstalkers' Revenge characters Donovan Baine, Huitzil and Pyron to the Vampire Savior cast while omitting Jon Talbain, Rikuo (Aulbath), and Sasquatch.

Although the game was never officially released in arcades outside of Japan, the game was incorporated into Darkstalkers 3 and later as its own standard game in the Japanese only release of Vampire: Darkstalkers Collection.