The Sega Mega-CD version of Wheel of Fortune was handled by rightsholders Sony themselves through Sony Imagesoft and Absolute Entertainment rather than through GameTek, in a similar fashion to their other game show Mega-CD game, Jeopardy!.

As with Jeopardy!, this game is a flashier production, featuring animated videos, animated sprites, and voice samples of Vanna White (sans Pat Sajak again) and the model contestants and a full spinning Wheel, but also cuts back in other places (most noticeably, Vanna isn't animated as turning letters at all; she merely walks by and the letters turn themselves).